Targeted Delivery of Therapeutic Oligonucleotides for the Treatment of Prostate Cancer

Abstract

Androgen independence and chemoresistance are the major obstacles in the treatment of patients with advanced prostate cancer (Denis & Murphy, 1993; Oh & Kantoff, 1998). Recent studies have suggested that overexpression of a proto-oncorprotein, Bcl-2, plays an important role in the development of androgen independence and chemoresistance in prostate cancer. We propose in this application to develop a tumor-specific vehicle to selectively deliver to the tumor an antisense oligodeoxynucleotides (ODN) that is targeted to Bcl-2. Down-regulation of Bcl-2 in prostate cancer could render it more susceptible to the standard chemotherapy. Sigma receptor will be chosen as the target as they are overexpressed in a number of tumors including prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2004
Accession Number
ADA427140

Entities

People

  • Song Li

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Epithelial Cells
  • Fatty Acids
  • Health Services
  • Medical Personnel
  • Organic Chemistry
  • Pharmacies
  • Therapy

Fields of Study

  • Biology

Readers

  • Immunology
  • Oncology (Cancer Research).