Targeting Microvascular Pericytes in Angiogenic Vessels of Prostate Cancer
Abstract
Pericytes are critical for angiogenesis, new vessel formation within the body of a tumor, in prostate cancer. Investigations supported by DAMD17-03-1-0012 shows extensive contribution of activated pericytes to vascular sprouting in prostate cancer in transgenic adenocarcinoma of mouse prostate(TRAMP), PC-3 and LNCaP models. Same set of experiments also reveal a novel angiogenic vessel class lacking endothelium. This novel microvessel type is named as pericyte tube as seen in the paper(Angiogenesis 6:24l-249, 2003). Examination of prostate tumor fragments (TRAMP) from NG2 wildtype mouse (donor) into the cornea of NG2 knockout host shows PDGF beta-receptor positive pericytes which were invariably negative for NG2. The fact that PDGF beta-receptor positive pericytes express NG2 in tumors grown in NG2 wildtype mice but not in tumors grown in NG2-null mice suggests that pericytes of the tumor vasculature derive from host rather than from any component of the donor tumor. Hydron pellets containing NG2 antibody is effective in reducing angiogenesis in LNCaP and PC-3 tumor established in the nude mouse cornea.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2004
- Accession Number
- ADA427145
Entities
People
- Ugur Ozerdem
Organizations
- Sanford Burnham Prebys Medical Discovery Institute