Prostate Cancer Risk in Relation to IGF-I and Its Genetic Determinants: A Case Control Study Within the Cancer Prostate Sweden Project (CAPS)
Abstract
A large genetic association study is being conducted, to examine relationships of prostate cancer risk with polymorphic variation in a series of selected candidate genes that are involved in pathways determining the synthesis of IGF-I and IGF-binding proteins, as well as biological response to IGF-I. The study will be performed within a large Swedish casecontrol study ("CAPS"). We completed, as planned, the recruitment of prostate cancer cases and control subjects, biobanking of blood samples, extraction of DNA samples and shipment of DNA aliquots to the laboratory (IARC) where genotyping of single nucleotide polymorphisms will be performed. The shipment of plasma samples, for measurement of IGF-I and IGFBP-3, was postponed for practical reasons, until year 2 of the project. Our project is entirely on schedule. and will start producing its first scientific results on SNP genotyping and statistical association analyses in year 2, as planned.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA427146
Entities
People
- Rudolf J. Kaaks
Organizations
- International Agency for Research on Cancer