Early Detection of Prostate Cancer with a New Data Acquisition System for Telomerase Activity Analysis
Abstract
Prostate cancer is the most common malignancy that requires a screening of a very large population at risk. In addition, there is a crucial necessity not only to detect prostate cancer at potentially curable stage, but also to distinguish between the most aggressive and indolent carcinomas. At present time, there is a lack of satisfactory tools for early detection of prostate cancer. In this context, our research team that includes physicists, molecular biologists and urologists is working enthusiastically on the development of the instrument and assay for prostate cancer screening, and in a parallel, we are studying correlations between telomerase activity and clinicopathological manifestations of prostate cancer. During this period we have accomplished he following: a) characterized limits of sensitivity of the proposed technology that is at least 10-100 folds higher compared to standard TRAPeze XL assay; b) optimized sample collection, processing and electrophoresis; c) created a tissue bank for determination of a clinical applicability of the proposed instrument; d) obtained important preliminary data on clinical samples; e) reported current data on two AACR meetings; f) prepare two papers for submission; and g) submitted the proposal for clinical trial development award.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2004
- Accession Number
- ADA427174
Entities
People
- Galina I. Botchkina
Organizations
- State University of New York