Monitoring the Response of Chemotherapy on Breast Cancer Tumors by Photon Migration Spectroscopy
Abstract
Optimal management of patients with locally advanced breast cancer (LABC) remains a complex therapeutic problem. The optimal intensity and duration of the neoadjuvant chemotherapy regiment for LABC still remains controversial due to the difficulty of evaluating response to the treatment. The goal of this project is to use Photon Migration Spectroscopy (PMS) as a new modality to monitor the response of breast tumor to neoadjuvant chemotherapy. Photon Migration Spectroscopy has shown excellent sensitivity to the crucial early functional changes in breast tissue subjected to neoadjuvant chemotherapy. We have measured over 18 patients and have seen optical changes in responders and lack of optical changes in non-responders. We are still in process of enrolling more patients and refining the stability and reproducibility of the data collected thus far. In addition, we have defined an "Optical Index," which incorporates all the optical parameters into a single easy to understand value which better describes the response of the tumor to the neoadjuvant chemotherapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA427179
Entities
People
- David J. Hsiang
Organizations
- University of California, Irvine