Exercise to Counteract Loss of Bone and Muscle During Androgen Deprivation Therapy in Men With Prostate Cancer
Abstract
The objective is to determine whether a 1-year intensive resistance exercise training (RT) program is more effective than a moderate-intensity walking program in ameliorating the effects on body composition of androgen deprivation therapy (ADT). It is postulated that, in men on ADT for the treatment of locally advanced prostrate cancer: 1) RT will attenuate the declines in bone mineral density (BMD) and fat-free mass (FFM) to a greater extent than walking; and 2) both RT and walking will prevent an increase in fat mass. Primary outcomes are lumbar spine BMD and FFM. Secondary outcomes are: total body and hip BMD; fat mass; markers of bone turnover; serum sex hormones; physical functional performance; and quality of life. Local project support will enable assessment of risk factors for cardiovascular disease (blood lipids, glucose tolerance, arterial stiffness). Communications with the Army HSRRB have been ongoing in the past year to finalize the protocol. Local IRB approval for all HSRRB-recommended changes was received on 1 Apr 2004 and documentation was submitted to the HSRRB. The study will commence when HSRRB approval is received. No subjects have been enrolled and no study personnel have received salary support from the award.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA427187
Entities
People
- Wendy M. Kohrt
Organizations
- University of Colorado Health