Nanobiohybrids: New Model Systems for Membranes and Sensors
Abstract
The focus of this program is to correlate structure and function in biological membranes using nanohybrids as artificial models and to develop new sensors based on nanohybrids. We have already demonstrated both objectives. Nanohybrid artificial membranes exhibit characteristics similar to biological membranes and they can be used as sensors. The nanohybrid membranes are synthesized by intercalating amphiphile molecules into the galleries of a layered host producing an alternating amphiphile/inorganic multilayer. We have established how the nanohybrid membranes respond to changes in temperature, pH, pressure and electric field. For example, permeation through the nanohybrids can be modulated by changing the pH or by switching on and off the electric field across the membrane. We have also shown that the nanohybrid membranes can be used as sensors for different analytec including saccharin and quinine. Different responses have been observed even for molecules that have similar features for example, saccharin and its sodium salt suggesting that the nanohybrid might be useful in developing an electronic nose. The dynamic range of the current sensor for saccharin is 6uM to 5OOuM. Recent work has enabled us to optimize the response time (from several minutes to seconds) as well as better understand the sensing mechanism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA427213
Entities
People
- Emmanuel P. Giannelis
Organizations
- Cornell University