Metastasis Genes in Breast Cancer Metastasis to Bone

Abstract

The overall objective is to test the role of BRMS1 in the ability of breast xenografts to metastasize to bone following intracardiac injection. A corollary is that BRMS1-regulated genes, especially osteopontin (OPN) will influence metastasis. Briefly, OPN is thought to be a metastasis promoting gene, while BRMS1 is a metastasis suppressor. Restoration of BRMS1 expression suppressed OPN. Knowing that BRMS1 suppresses metastasis from an orthotopic site to lung and regional lymph nodes (Seraj et al., 2000; Samant et al., 2001; Shevde et al., 2002), it is not known whether metastasis is suppressed all sites. Since breast cancer spreads most commonly to bone, we will test whether BRMSl and/or molecules regulated by BRMS1 block bone metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA427647

Entities

People

  • Danny R. Welch

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

  • Military Engineering.
  • Molecular Biology and Genetics