Engineering Analysis of a Genetic Switch: Modeling and Simulation Tools

Abstract

The overall objective of this project was quantitatively explain the extraordinary stability of the lambda-phase lysogen given that the data on the lysis/lysogency switch dynamics didn't seem to be sufficient for explanation. Further, we aimed to explain the differential stability of a number of operator mutants constructed by John Little. Further, in all cases, we wished to explain the threshold response of the induction switch to different exposures to UV light. Then, based on this understanding we aimed to re-engineer this switch with different thresholds, cooperativities and stabilities.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2004
Accession Number
ADA427740

Entities

People

  • Adam P. Arkin

Organizations

  • University of California, Berkeley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Chemical Reactions
  • Dynamics
  • Engineering
  • Engineers
  • Fungi
  • Gene Expression
  • Information Operations
  • Microarray Analysis
  • Military Research
  • Monitors
  • Physics
  • Physics Laboratories
  • Simulations
  • Statistical Mechanics
  • Transcription Factors

Readers

  • Distributed Systems and Data Platform Development
  • Microbial Pathology
  • Optical Physics and Photonics.

Technology Areas

  • Biotechnology