RAR Beta: Actions in Prostate Cancer

Abstract

I have previously identified some RARbeta targets genes. In the past year, I carried out actinomycin D experiments and determined that the RAR-beta targets genes are transcriptionally regulated by RAR-beta2. In addition, I have shown that RAR-beta selective agonists and RXR agonists synergistically induce RAR-beta2 target genes in F9 wild-type cells. I also showed that ELF3, one of RAR-beta target genes, was up-regulated by RA in normal human prostate epithelial cells, but not in human prostate tumor cells.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA427753

Entities

People

  • Yong Zhuang

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Acids
  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Epithelial Cells
  • Inhibition
  • Lung Cancer
  • Neoplasms
  • New York
  • Prostate
  • Prostate Cancer
  • Retinoic Acids
  • Tissues
  • Transcription Factors
  • Universities

Fields of Study

  • Biology

Readers

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