Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy
Abstract
This trial tests a regimen of prone conformal hypo-fractionated radiotherapy directed to the original tumor bed with margins in a selected subset of post-menopausal women with breast cancer with a very low risk for local recurrence elsewhere in the breast. After planning CT is conducted in the prone position, the breast tissue and tumor bed are contoured on a 3D planning system and a 2 cm margin added to determine the planning treatment volume (PTV) . A plan is generated to treat the PTV with six Gy per fraction are delivered to the 95% isodose surface in 5 fractions over ten days weeks to a total dose of 30 Gy. Fifty-three of the 99 patients planned to accrue to the study have completed treatment and the results have been reported at the ASTRO 2003 meeting and 2004 American Radium Society meeting. All patients tolerated treatment very well. DVH varied based on the position of the original tumor bed and the size of the breast. In most cases it was possible to successfully plan and treat a quadrant of the breast without exceeding 50% of the dose to 50% of the breast volume. Longer follow up is necessary to assess efficacy and cosmetic results.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA427755
Entities
People
- Silvia C. Formenti
Organizations
- New York University