The Role of AKT2 in Human Breast Cancer
Abstract
During past year, I have focused my attention on AKT2 regulation of MST1 pathway and the effort of AKT2-interaction protein, APBP/APalphaB, on AKT2 signaling. MST1 is a member of STE20 like kinase and has been shown to induce apoptosis through its cleavage, activation and nuclear translocation. I have shown that AKT2 interacts with and phosphorylates MST1 at threonine-120, resulting to inhibition of MST1 cleavage and nuclear translocation. Thus, AKT2 abrogates MST1-induced apoptosis. AKT2-interaction protein, APBP/APalphaB, mediates AKT2 activation of p21-activated kinase 1(PAK1) pathway to induce cell survival.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA427759
Entities
People
- Zeng-qiang Yuan
Organizations
- University of South Florida