Inherited Susceptibility to Breast Cancer in Healthy Women: Mutation in Breast Cancer Genes, Immune Surveillance, and Psychological Distress

Abstract

The purpose of the research supported by this IDEA grant award, is to provide the first critical test of the possibility that variability in the strength of immune surveillance mechanisms against caner (operationally defined by assessment of natural killer cell activity) may be a factor in determining the penetrance of mutations in breast cancer susceptibility genes. Two possible explanations for variability in NK cell activity are being investigated: 1) stress-induced immune suppression, and 2) inherited deficits in immune surveillance. This year, we have collected data on an additional 91 women for a total of 184 participants to date. We have requested a no-cost extension of the award anticipating that, on our improved referral rate to the study, we will be able to complete the proposed research during this period.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2003
Accession Number
ADA427835

Entities

People

  • Dana H Bovbjerg

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cells
  • Electronic Mail
  • Genetic Phenomena
  • Genetic Testing
  • Genetics
  • Information Operations
  • Lymphocytes
  • Medical Genetics
  • Mutations
  • Neoplasms
  • New York
  • Risk Factors
  • Surveillance

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.