Effect of Dietary Intervention on Prostate Tumor Development in Tramp Mice
Abstract
Prospective epidemiological studies indicate that as body weight and/or energy intake increase so does the risk for prostate cancer. In rodent studies chronic calorie restriction in associated with extended life expectancy and decreased incidence of malignancies. A protective effect of energy restriction on development of spontaneous prostate tumors in Lobund-Wistar rats and tumors developing from transplanted prostate tumor tissue cells in mice and rats have been published, but a mechanism of action has not been identified. Recent introduction of the TRAMP (transgenic adenocarcinoma mouse prostate) mouse provides a model that shares characteristics with human prostate cancer. Here, TRAMP mice are being used to evaluate their response to chronic and intermittent calorie restriction. The insulin like growth factor (IGF) axis is being investigated to determine if it is involved in this protective process. Presently, we are following ad libitum-fed, intermittent-restricted and chronic restricted TRAMP mice in a longitudinal study to determine prostate cancer incidence, latency and metastasis rate. A 25% reduction in caloric intake is being utilized. Mice also are being enrolled in a cross-sectional protocol. Results will determine if the manner of caloric restriction modulates its protective action and possibly identify a metabolic pathway to target for prevention and/treatment strategies.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA427836
Entities
People
- Margot P. Cleary
Organizations
- University of Minnesota