Genetic Variation in the HSD3B2 Gene and Prostate Cancer
Abstract
Prostate cancer is the most common cancer in American men. It is also characterized by a substantial racial/ethnic variation in risk: highest in African-American men, lowest in Asian men and intermediate in Caucasian and Latino men. We propose to investigate genetic variants of genes involved in the regulation of prostatic growth and particularly in androgen metabolism, particularly the HSD3B2 gene which encodes the type II b-hydoxysteroid dehydrogenase. Our final progress reported is highlighted by the following four findings. First, our data indicate that the locus under investigation is highly polymorphic in constitutional DNA and mutated in tumor (i.e. somatic) DNA. Second, our population-based investigations are complete. Third, we will complete the biochemical analyses soon. Finally, we note that we have also investigated transcription of the HSD3B2 gene and found that YY1 binding is important.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA427886
Entities
People
- Juergen K. Reichardt
Organizations
- University of Southern California