Antineoplastic Efficacy of Novel Polyamine Analogues in Human Breast Cancer
Abstract
The important role of polyamines in regulation of cell growth has led to the development of a number of polyamine analogues that can intervene in natural polyamine metabolism and inhibit the growth of tumor cells. This proposal was designed to elucidate the molecular mechanisms and the therapeutic efficacy of new generation of polyamine analogues in treatment of human breast cancer. In the first year of this award, we have performed the preliminary study of the in vitro and in vivo anti-tumor efficacy of novel polyamine analogues in breast cancer cells (Clin. Cancer. Res., 9: 2769, 2003) and continued on the investigation of the molecular mechanisms responsible for the growth inhibition and apoptosis induced by polyamine analogues. Our studies indicate that polyamine analogue-inducible AP- 1 plays a pro-survival role in polyamine analogue treated breast cancer cell. (Mol. Cancer Res., 2: 81, 2004). Our studies also showed that activation of the p53 is important for the induction of polyamine analogue-induced growth inhibition and apoptosis, whereas JNK/Jun signaling pathway may negatively regulate p53 (unpublished). These data suggest that p53 and JNK/Jun pathways may be the useful molecular targets for improving the therapeutic efficacy of polyamine analogues in human breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA427952
Entities
People
- Yi Huang
Organizations
- Johns Hopkins University