Caveolin-1 Modulates Androgen Receptor Signaling in Advanced Prostate Cancer
Abstract
In the current funding year, we focus our effort on proposed work for Tasks 2 and 3 to characterize both the functional and physiological roles of caveolin in AR signaling. We have demonstrated a cross-talk between the caveolin-1/AR and PI3 kinase/Akt signal pathway in hormone dependent cell survival. Our results established a biochemical basis on the notion that caveolin expression is associated with prostate cancer progression. The "neo-expression" caveolin in advanced prostate cancer represents a gain-of-function event in cancer progression. Moreover, these results illustrate the important role of AR non-genomic effect in response to androgen stimulation. These findings pave the way to further define the underlying signal cross-talk in AR-mediated signaling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA427983
Entities
People
- Michael L. Lu
Organizations
- Brigham and Women's Hospital