Genetic and Hormonal Risk Factors for Prostate Cancer in African American Men
Abstract
African American men are at greater risk for both developing and dying from prostate cancer compared to white men. The reason for this disparity is likely due to a number of factors including environmental exposures and genetic factors. The Flint Men's Health Study (FMHS) was established in 1995 as a population-based case-control study of African American men aged 40-79 residing in Genesee County, Michigan. The initial sample consisted of 730 men who completed an extensive in-home interview consisting of potential risk factors for prostate cancer; medical history; and demographic information. From this initial cohort, 431 men provided a blood sample and 369 men who were determined to be free of cancer completed a comprehensive urologic examination. Additionally, 119 cases of prostate cancer have been identified from the same study population. Studies have suggested a role for hormones and genetics in prostate cancer incidence. However, these studies have been completed in white populations and results have been conflicting. The objective of this study is to use a set of previously collected serum and DNA samples from a population-based study of African American men to more clearly delineate the potential role(s) of selected hormones and growth factors in prostate cancer development.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA428085
Entities
People
- Aruna Sarma
Organizations
- University of Michigan