Electrical Impedance Tomography of Breast Cancer
Abstract
In screening of breast cancer, once abnormalities or lesions are discovered by the X-ray mammogram, generally, other imaging techniques are needed as an adjunct to diagnose the lesion as benign or malignant. It has been shown that cancer cells exhibit altered local electrical impedance. However, existing technology to measure the impedance of the breast has poor spatial resolution. We proposed to map the tissue impedance distribution with high spatial resolution, in conjunction with MH to improve diagnostic accuracy of screening. During the second year of this project, we improved the quality of conductivity images and conducted in vivo experiments. Several issues such as non-linearity in conductivity image reconstruction, out of slice effects were investigated. Improved reconstruction methods were studied. Multi-slice capability is added to the pulse sequence and various approaches were tested. Although it was not originally in the project proposal, we started collecting Contrast Enhanced MRI images to localize the tumor better. A serious malfunction in the MRI receiver unit caused a delay of more than six months. A no-cost extension was requested to collect more conductivity images from animals and complete this project successfully. Another conference manuscript was prepared and presented and a journal article was submitted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA428129
Entities
People
- L T Muftuler
Organizations
- University of California, Irvine