Programmable Self-Assembly of DNA-Dendrimer and DNA-Fullerene Nanostructures
Abstract
The scientific goal for this project was to fabricate nanostructures from deoxyribonucleic acid (DNA)-dendrimers, DNA-nanotubes and DNA-diamond adducts, and then to assemble these nanostructures into larger scale functional constructs. The five major areas of research were: 1) The creation and characterization of highly regular DNA- dendrimer and DNA-nanotube nanomaterials; 2) The development of the appropriate modification chemistry for both gold and silicon surfaces for the specific absorption by hybridization of DNA-dendrimer and DNA-carbon nanotube materials; 3) The use of DNA hybridization to control the assembly of nanotubes onto a surface by modifying that surface with one sequence of DNA and with the carbon nanotubes with the complementary sequence; 4) The design and testing of large, well-behaved sets of short DNA oligomers or words" that will be used in the DNA-nanoparticles and surface attachment patterns; and 5) The development of various enzymatically amplified detection technologies for DNA and RNA biosensors. Well characterized, functional DNA-dendrimers, DNA-nanotubes and DNA-diamond adducts were created which have a specific number of one or more DNA sequences on the exterior of the dendrimer or nanotube and were capable of internally incorporating a variety of materials such as enzymes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2004
- Accession Number
- ADA428157
Entities
People
- Robert M. Com
Organizations
- University of Wisconsin–Madison