Monitoring Cancer Oxygenation Changes Induced by Ultrasound
Abstract
Oxygen has significant impact on cancer treatment. Our hypothesis was: (a) Tumor blood vessels were leaky and therefore acoustic vibration can be used to modulate the leaky vessels and induce oxygenation changes; (b) The oxygenation changes can be detected by optical measurements. Preliminary studies with 5 tumor-bearing rats demonstrate that ultrasonic vibrations can either generate significant effects (early stage tumors) on optical measurements or no effects on optical measurements (late stage tumors). In the past year, the PI has devoted his efforts on quantify both acoustic vibration and optical measurement of oxygenation: (1) Optimization of ultrasound system for quantification of mechanical stress generated by the ultrasound vibration (in task 2); (2) Optimization of optical wavelength selection for in vivo oxygenation estimation (in tasks 1 and 3).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA428189
Entities
People
- Daqing Piao
- Qing Zhu
Organizations
- University of Connecticut