Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity
Abstract
This final progress report covers the activities of three projects and one core resource. We provide the required reporting elements for each of these individuals. The following summarizes the key accomplishments from this award (DAMDl7-00-l-0102). We demonstrated in Project A that somatic mutations of the SRD5A2 gene are fairly common; some are recurrent and based on in vitro functional studies, dramatically change enzymatic kinetics. We demonstrated in Project B that somatic mutations in the AR gene are extremely rare across all racial-ethnic groups prior to hormonal ablation therapy. We then proceeded to contribute substantially to understanding the molecular biology of AR signaling in the prostate through a series of publications. In Project C we completed immunohistochemical analyses on a series of molecular markers (p2 1, COX-2, caveolin- 1, URP78) of prostate cancer progression on a population-based multiracial-ethnic sample of patients - statistical analysis are ongoing. In our Epidemiology Core, we collected and processed 522 prostate cancer tissue samples from a multiethnic cohort. This tissue bank (to our knowledge the largest of its kind in a multiethnic context) will be an extremely valuable resource for additional planned analyses.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA428196
Entities
People
- Ronald K. Ross
Organizations
- University of Southern California