Molecular Mechanism for Loss of Cell Adhesion in HER-2/neu Overexpressing Tumor Cells

Abstract

The HER2 proto-oncogene is amplified and overexpressed in approximately 25% of breast cancers. Amplification and overexpression of HER2 is correlated with poor patient prognisis, lack of responsiveness to tamoxifen treatment, responsiveness to adriamycin chemotherapy and responsiveness to Herceptin anti-HER2 immunotherapy. In this proposal we are characterizing changes in cell adhesion related to HER2 overexpression. We have investigated the effect of HER2 overexpression on alterations in cell adhesion in 3 cell lines engineered to overexpress HER2. Relative to parental control cell lines, HER2-overexpressing cell lines showed altered cell adhesion on selected extracellular matrix proteins, suggesting that integrin receptors are involved in this process.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA428250

Entities

People

  • Michael F. Press

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adhesion
  • Anti-Bacterial Agents
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Fibroblasts
  • Growth Factors
  • Indicator Dyes
  • Neoplasms
  • Proteins
  • Tyrosine

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology