The Role of IQGAP1 in Neoplastic Growth and Metastasis
Abstract
The purpose of this proposal is to evaluate the role of IQGAP1 in neoplastic transformation and metastasis of breast epithelial cells. The main emphasis is on whether IQGAP1 Is involved in invasion and metastasis of transformed breast epithelial cells, as well as the possible involvement of 1QGAP1 in regulating beta-catenin function. Major findings to date are: (i)there is a high level of expression of IQGAP1 in breast epithelium; (ii)overexpression of IQGAP1 in mammalian cells enhances cell migration and proliferation; and (iii) decreased 1QGAP1 protein levels reduced cell motility. These data reveal that IQGAP1 has a fundamental role in cell motility and invasion in breast epithelium. This information could have potential therapeutic implications in patients with breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA428310
Entities
People
- David Sacks
- Monideepa Roy
Organizations
- Brigham and Women's Hospital