Mechanism of Interaction of Sleep-Affecting Compounds With Neuronal Receptors

Abstract

This report results from a contract tasking lnst of Physiologically Active Substances. Russian Academy of Sciences as follows: The goal of this project is to study the mechanism of interaction of some endogenous sleep-affecting compounds with the GABA (gamma aminobutyric acid)- and glutamate receptor channel complexes in neuronal cell culture. Electrophysiological and biochemical methods will be used to assess those interactions. Results will provide new insights into those naturally existing compounds that induce and regulate the sleep-wake cycle or affect related fatigue via key neurotransmitter systems.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA428338

Entities

People

  • Sergey Bachurin

Organizations

  • Russian Academy of Sciences

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Amplitude
  • Brain
  • Cells
  • Cerebellum
  • Chemical Compounds
  • Chemistry
  • Contracts
  • Culture Techniques
  • Glutamates
  • Hormones
  • Inhibition
  • Peptide Growth Factors
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Prostaglandin
  • Synaptosomes

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neuroscience
  • Technical Research and Report Writing.