Gene and Protein Therapy for Poisoning by Organophosphorus Agents
Abstract
The goal of this work is to protect the soldier from the toxicity of nerve agents. The research plan involves finding new ways to deliver protective cholinesterase enzymes into tissues. Gene therapy and protein therapy protocols are being developed. Test animals are being made to test the idea that an organophosphate hydrolase enzyme in the right location will provide protection against organophosphorus toxins. The G117H knockin mouse and the G117H transgenic mouse will give information on the level of protection that can be achieved by introducing the gene for an organophosphorus hydrolase.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA428416
Entities
People
- Oksana Lockridge
Organizations
- University of Nebraska Medical Center