Intensity Modulated Radiation Treatment of Prostate Cancer Guided by High Field MR Spectroscopic Imaging
Abstract
With the development of computer controlled multileaf collimators, IMRT now provides unprecedented means for us to deliver 3D-dose distributions with subcentimeter resolution. Simultaneously, MRSI is capable of noninvasively providing critically needed 3D metabolic and physiological information. Together with anatomical CT or MRI images, functional imaging affords valuable 4D data (3D structural plus 1D metabolic). A timely issue is how to integrate the metabolic/functional data into IMRT treatment planning to improve clinical prostate cancer management. Toward establishing biologically conformal radiation therapy for prostate treatment, we have carried out a series of studies and developments and have successfully accomplished a number of important milestones of the proposed project These include (i) implemented 3T prostate MRSI technique with J-resolved pulse sequence; (ii) developed a robust image registration procedure to map endorectal coil-based MRSI data onto treatment planning CT/MRI images; (iii) performed experimental validation of the image registration tools; (iv) designed and fabricated MRSI quality assurance phantom; and (v) improved currently available inverse planning algorithm for MRSI-guided prostate IMRT. Integration and further refinement of the above tools are still underway. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of MRSI-guided prostate treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA428422
Entities
People
- Lei Xing
Organizations
- Stanford University