DNA Vaccination to Overcome Peripheral Tolerance

Abstract

The goal is to develop vaccination regimen to a tumor-associated self-antigen, ErbB-2 and to induce significant anti-tumor immunity in mice which are tolerant to ErbB-2. The objectives are to (1) Measure vaccination efficacy after depletion of CD4+CD25+ cells regulatory T (Treg) cells. (2) Compare immune reactivity and tumor growth inhibition in ErbB-2 transgenic mice vaccinated with autologous or heterologous ErbB-2 (3) Construct and test vaccination efficacy of ErbB-2 containing Pan DR Reactive Epitope (PADRE).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2004
Accession Number
ADA428423

Entities

People

  • Wei-Zen Wei

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Autoimmune Diseases
  • Autoimmunity
  • Blood
  • Cells
  • Chemistry
  • Environmental Health
  • Genetics
  • Immunity
  • Immunization
  • Immunomodulation
  • Immunotherapy
  • Lymphocytes
  • Proteins
  • Thyroid Diseases
  • Vaccination
  • Vaccines

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech