Genetic Alteration of Metabolism and Tumorigenicity of Prostate Cancer Cells
Abstract
It has been well documented that normal prostate contains the highest zinc levels among all other soft tissues in the body. However, once the normal prostate cells transform to malignant cells, the zinc levels decreased significantly. We have demonstrated two major functions of zinc in prostate: metabolic effect and growth effect. This proposal aimed to establish that the prostatic tumor cells are citrate oxidizing cells; and to demonstrate that the alteration of zinc accumulation will alter the citrate production and eventually inhibit the tumor cell growth. The third year study was focused on: 1) to continue the study of the zinc effect on prostate tumorigenicity in vivo; 2) to study the mechanism of zinc induced PC-3 cell apoptosis; 3) to extend our understanding of zinc effect on the relationship of metabolism and growth in prostate tumor cell, the effect of zinc on prostate TRAMP cells was studied. Over the past three years with DOD grant support, we have published 6 papers in peer reviewed journals and prepared 2 manuscripts for submission. We have also presented our research data with 14 published abstracts in academic meetings (see Appendix).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA428429
Entities
People
- Pei Feng
Organizations
- University of Maryland, Baltimore