Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis

Abstract

The hypothesis of this grant proposal is that androgen-ablative therapy paradoxically increases growth factor secretion from bone stromal cells and that this may stimulate the growth of prostate cancer metastases. We proposed to test this hypothesis using IL-6 and HGF/SF as paradigms of androgen regulated growth stimulators. However, two separate experimental approaches did not demonstrate an increase in IL-6 or HGF/SF gene expression in androgen-deprived mouse bone. As a result of this initial negative investigation in task 1 we decided to take a broad approach to identify genes up-regulated by androgen deprivation in mouse bone. This approach has revealed multiple genes overexpressed upon androgen-ablation that may regulate growth factor systems involved in the crosstalk between the bone environment and prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2004
Accession Number
ADA428439

Entities

People

  • Beatrice S Knudsen

Tags

DTIC Thesaurus Topics

  • Androgens
  • Blood Coagulation Factors
  • Bone And Bones
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Databases
  • Dna Microarrays
  • Enzyme Inhibitors
  • Epithelial Cells
  • Gene Expression
  • Growth Factors
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Stromal Cells
  • Tissues

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology
  • Prostate Cancer Biology.