High Throughput Synthesis and Screening for Agents Inhibiting Androgen Receptor Mediated Gene Transcription

Abstract

Details of the year 2 progress on our grant to define a new treatment of therapeutic resistant prostate cancer is provided. This entails the high throughput synthesis of DNA binding agents related to distamycin, their screening for binding to androgen response elements using a new high throughput DNA binding screen we introduced, and the evaluation for inhibiting androgen receptor mediated gene transcription and the cell proliferation of a prostate cancer cell line.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2004
Accession Number
ADA428440

Entities

People

  • Dale L. Boger

Organizations

  • Scripps Research

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Lymphocytes
  • Mass Spectrometry
  • Molecular Biology
  • Neoplasms
  • Organic Chemistry
  • Polymers
  • Prostate Cancer
  • Proteins

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics
  • Molecular Genetics