Optical Coherence Tomographic Imaging and Delivery for Surgical Guidance
Abstract
OCT is an emerging diagnostic imaging technology which was developed by our research group in part under this program. OCT generates cross-sectional images of tissue microstructure with micron scale (1-15 micrometers) resolution by measuring the echo time delay and magnitude of backscattered light. OCT can thus function as a type of "optical biopsy," enabling imaging of tissue with resolution approaching conventional biopsy and histopathology, but without the need to remove and process specimens. Over the three years of work under this contract, we have made significant progress in a number of areas: development of new laser technology for ultrahigh resolution imaging; new technology and measurement techniques for OCT imaging; in vitro imaging studies to establish the feasibility of using OCT for optical biopsy; and preliminary clinical studies. These key advances are summarized in sections entitled: A. Ultrahigh Resolution Technology for OCT imaging; B. Optical Biopsy and Novel Devices for Clinical Applications; C. Clinical Imaging using Optical Coherence Tomography.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 2004
- Accession Number
- ADA428494
Entities
People
- James Fujimoto
Organizations
- Massachusetts Institute of Technology