Intermittent Ultrasound Imaging of Prostate Cancer
Abstract
This study proposed to evaluate contrast-enhanced ultrasound imaging with a microbubble contrast agent in 300 subjects in order to improve the detection of prostate cancer. Between October 2001 and January 2004 a total of 301 subjects were enrolled. Laboratory blood tests (PSA) and ultrasound evaluations were completed on all 301 subjects (including the primary ultrasound interpretation worksheet). Independent blinded readers have reviewed the first 241 subjects. Pathological review for the presence and grade of cancer has been completed for all 301 subjects. CD3l staining for micro-vessel density has been performed on the first 40 subjects. All available data has been entered into a computer database using an Excel spreadsheet. A statistical analysis of the prostate cancer detection data from all 301 subjects was incorporated into two abstracts that have been accepted for presentation at the 2004 annual meeting of the Radiological Society of North America (see appendix). A preliminary microvessel density analysis was presented at the annual meeting of the American Institute of Ultrasound in Medicine (see appendix). A one year no cost extension has been requested to allow completion of the micro-vessel density analysis as well as the blinded review of the final 60 subjects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA428523
Entities
People
- Ethan J. Halpern
Organizations
- Thomas Jefferson University