Contribution of Bone Marrow-Derived Cells to the Tumor Stroma in Human Breast Cancer
Abstract
Breast cancer is a disease whose progression requires the involvement of many different cell types. These cell types, in addition to the mutated cancerous cells that initiate formation of the tumor mass, include non-cancerous blood vessel and connective tissue cells. These ancillary cell types, while not cancerous on their own, are required by the cancer cells in order for a tumor to grow beyond a very small size. Therefore, it is important to understand the interactions between these two cancerous and non-cancerous cellular components of a breast tumor mass, since such interactions may serve as novel targets for therapeutic intervention. The proposed work concerns the origins of the tumor-associated stroma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2004
- Accession Number
- ADA428526
Entities
People
- Piyush Gupta
- Robert Weinberg
Organizations
- Massachusetts Institute of Technology