Intervention Study of Flaxseed in Postmenopausal Women: Effects on Hormonal Biomarkers of Breast Cancer Risk

Abstract

The objective of this study is to determine if flaxseed supplementation to usual diet in postmenopausal women has a beneficial effect on important hormonal biomarkers of breast cancer risk. The specific aims of this study are to determine if (1) flaxseed intake lowers serum levels of estradiol and testosterone and increases serum levels of sex-hormone binding globulin; (2) flaxseed intake increases the urinary excretion ratio of 2/4-OHE1 and 2/16a-OHE1 and decreases the urinary excretion ratio of genotoxic estrogen metabolites to total estrogens (16a-OHE1 + 4-OHE2 + 4OHE1)/total estrogens; and (3) higher doses and longer duration of flaxseed intake results in greater changes to the aforementioned variables. Participants will receive 6 weeks of usual diet plus 12 grams per day of raw flaxseed, followed by 6 weeks of usual diet plus 24 grams per day of raw flaxseed. Serum and urinary levels of hormonal biomarkers of breast cancer risk will be assessed at baseline, 7 weeks, and 13 weeks.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA428548

Entities

People

  • Susan R. Sturgeon

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Classification
  • Electronic Mail
  • Fish
  • Information Operations
  • Intervention
  • Maryland
  • Massachusetts
  • Monitoring
  • Neoplasms
  • Security
  • Universities

Fields of Study

  • Medicine

Readers

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