Breast Cancer Susceptibility Genes in High Risk Women
Abstract
A positive family history, present in about 30% of breast cancer cases, has been shown to double a woman's risk of breast cancer(l), and this is true for postmenopausal as well as the premenopausal cases, among which the autosomal dominant, relatively high penetrant genes BRACA1 and BRCA2 are most prominent(2). It has been hypothesized that susceptibility genes of lower penetrance are more prevalent than among the latter, and a likely group of such genes are those that regulate the production, intracellular transport, and metabolism of estrogen (3), the common factor underlying most known predictors of breast cancer risk (4) (5) (6). Recent reviews have identified several candidate genes (7) (8) (9). We have chosen to focus on those genes related to estrogen metabolism and carcinogen metabolism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA428572
Entities
People
- Ann S Hamilton
Organizations
- University of Southern California