Interindividual Variation in the Metabolic Activation of Heterocyclic Amines and Susceptibility to Prostate Cancer
Abstract
The etiology of prostate cancer is not well understood. Exposure to carcinogenic heterocyclic amines such as PhIP, formed in high-temperature cooked meat has been implicated as an important risk factor. The Phase I metabolic pathway of PhIP is mainly catalyzed by the human cytochrome P450s 1A2, 1A1, and 1B1 to form 2-hydroxyamino-PhIP (N-hydroxy PhIP), the carcinogenic metabolite, and 4'-hydroxy PhIP (4'- hydroxy PhIP), the non-carcinogenic metabolite. Although epidemiological studies suggest that PhIP may play an important role in the etiology of human colon, breast, or prostate cancer, the capability of these human extrahepatic tissues in metabolizing PhIP has not been well studied. In the present study, metabolic activation of food borne heterocyclic amines in 31 different human prostate microsomes indicates that there is no significant N-hydroxylation of PhIP, IQ, MeIQ and MeIQx.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA428578
Entities
People
- Jun-yan Hong