Regulation of Vitamin D Metabolism

Abstract

Compared to whites, blacks and Asian Indians have a reduction in serum 25-hydroxyvitamin D 25(OH)D as a consequence of increased skin pigment that causes a diminished rate of dermal production of vitamin D3 from 7-dehydrocholesterol and possibly of increased activity of 25(OH)D-24-hydroxylase, the rate-limiting enzyme for degradation of vitamin D metabolites, in cultured skin fibroblasts. Thus, production and degradation of 25(OH)D may be altered in these two racial groups. The purpose of this research is to determine the response to vitamin D in different racial groups, whites, blacks and Asian Indians. This will be accomplished by comparing the response of serum 25(OH)D to treatment with vitamin D. No results are available because the human subject restriction for this grant by the Army has not been removed.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2004
Accession Number
ADA428586

Entities

People

  • Norman H. Bell

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Diseases
  • Classification
  • Degradation
  • Electronic Mail
  • Ethnic Groups
  • Information Operations
  • Metabolism
  • Metabolism Phenomena
  • Metabolites
  • Production
  • Regulations
  • Security
  • South Carolina
  • Vitamin D

Fields of Study

  • Medicine

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