Vascularized Tissue Sensors for Generic Toxin and Pathogen Detection

Abstract

We developed three iterative prototypes of a bioreactor system that facilitates micro-perfusion of tissue-like structures formed from primary liver cells, and showed that the bioreactor and detection system could be used in a field setting running on batteries. We demonstrated that the endogenous p450 metabolic capacity could be used as a sensor and that cells in the bioreactor were sensitive to toxins requiring liver metabolism.

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Document Details

Document Type
Technical Report
Publication Date
Dec 21, 2004
Accession Number
ADA428591

Entities

People

  • D. Schaver
  • J. Sherley
  • J. Wands
  • Linda Griffith
  • S. R. Tannenbaum

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Engineering
  • Bioreactors
  • Blood Vessels
  • Cells
  • Culture Techniques
  • Detection
  • Detectors
  • Endothelial Cells
  • Engineering
  • Epithelial Cells
  • Fluid Dynamics
  • Fluid Flow
  • Hepatitis
  • Kinetics
  • Microscopy
  • Stem Cells
  • Three Dimensional

Readers

  • Computer Vision.
  • Microbial Pathology
  • Molecular and Cellular Biochemistry

Technology Areas

  • Biotechnology