Relationships Between IGF-1, IGF-Binding Proteins and Diet in African American and Caucasian Men
Abstract
The study aims to determine racial differences between insulin-like growth factor-l (IGF-1), insulin-like binding protein-1 (IGFBP-2), insulin-like binding preotein-3 (IGFBP-3), prostate specific antigen (PSA), testosterone, body mass index (BMI), and diets high in calories, protein and fat. Specifically, the primary objectives are to: * define raciai differences in serum levels of free and flal IGF-l, IGFBP-2, IGFBP-3, and testosterone * define how diet and BMI impact serum levels of IGF- 1, IGFBP-2, IGFBP-3, testosterone and PSA in African American and Caucasian men. * determine the associations between serum levels of free and total IGF-l, IGFBP-2, IGFBP-3, testoserone, PSA, BMI and specfic nutrients. Over 500 African American and Caucasian men were recruited. There were no racial differences found for serum levels of IGF-1. These analyses show that IGFBP-2 is significantly lower in African American than white men, while IGFBP-3 and testosterone are significantly higher. IGFBP-2 also exhibits a significant inverse association with BMI for both races, and a positive association with age for whites. African American men have higher consumption of calories, protein, total fat and nutrients than whites; all but the latter differences are significant. Finally, IGFBP-2 exhibits a significant univariate negative correlation with calories, protein and total fat, with a somewhat stronger association among white than African American men. Adjustment for age and BMI made all but the association with calories no longer significant, but it is possible that this represents over-adjustment of the model since age I not significantly correlated with nutrient intake in these men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2004
- Accession Number
- ADA428675
Entities
People
- Tanya Agurs-collins
Organizations
- Howard University