Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

Abstract

Proinflammatory mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2004
Accession Number
ADA428736

Entities

People

  • Teresa Krakauer

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Allergy And Immunology
  • Antigens
  • Biological Factors
  • Biological Toxins
  • Blood
  • Body Fluids
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytokines
  • Immune System
  • Infectious Diseases
  • Inhibitors
  • Lymphocytes
  • Molecules
  • Production
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology and Pathology