Three Dimensional Reconstruction Algorithm for Imaging Pathophysiological Signal within Breast Tissue Using Near Infrared Light
Abstract
Optical tomography is a non-invasive imaging technique that can image properties of biological tissue. Measurements of light propagation through tissue can be used to calculate and reconstruct images of internal optical properties. Since the absorption and scattering of light in the tissue is a function its physiological state, the aim is to calculate maps of physiological parameters, which can be early markers of tumor development. Specifically the aim is to image total hemoglobin, oxygen saturation, water and lipid concentrations, as well as potentionally molecular concentrations when used with fluorescent markers. Cancerous regions within the breast have shown to be physiologically different from normal tissue. These include a higher amount of angiogenesis and higher metabolic rate as compared to normal tissue. These differences will result in a change in optical attenuation and scatter of light due to hemoglobin changes, which will cause a change in the measured tomographic boundary data. Light transport modeling of propagation in tissue can be used to calculate maps of optical changes within the breast, and therefore physiological maps of total hemoglobin and oxygen saturation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA428927
Entities
People
- Hamid Dehghani
Organizations
- Dartmouth College