Changes in Ovarian Stromal Function in Premenopausal Women Undergoing Chemotherapy for Breast Cancer
Abstract
The purpose of this clinical research training grant is to gain the expertise to develop a program of research regarding understudied, critical quality of life issues in breast cancer survivors. A pilot research project was developed to look at the effect of chemotherapy on ovarian stromal function in premenopausal women undergoing chemotherapy for breast cancer. In this pilot study to assess ovarian stromal function, androgen levels will be drawn and evaluated at baseline and over the course of chemotherapy as the ovarian stroma is a significant source of androgens in naturally postmenopausal women. As androgens are linked in the literature to several symptoms that women with breast cancer experience, specifically decreased libido, increased fatigue, negative mood, vasomotor symptoms, and weight gain, it is important to explore the potential role of androgens in the etiologies of these symptoms. Nothing is known about this area currently in breast cancer survivors. Through the process of writing the pilot study and attending educational sessions, this principal investigator has continued to develop expertise in the area of sexuality and endocrine function as they relate to breast cancer survivors. A published review article on libido and a presentation on endocrine changes in breast cancer survivors have resulted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA428981
Entities
People
- Ann Kearns
- Charles Loprinzi
- Debra Barton
- Jeff Sloan
Organizations
- Mayo Clinic