Neural Protein Synuclein Gamma (ISNCG) in Breast Cancer Progression
Abstract
Synucleins are involved in the formation of pathologically insoluble deposits characteristic of neurodegenerative diseases. Gamma Synuclein (SNCG), previously identified as a breast cancer specific gene (BCSG1), is also highly associated with breast or ovarian cancer progression. However, the molecular targets of SNCG aberrant expression for breast Cancer have not been identified. Here we report that SNCG is overexpressed in the majority of breast cancer and stimulates ligand-dependent estrogen receptor signaling and mammary tumorigenesis. As an Hsp7O-associated chaperone, SNCG participated in Hsp-ER-alpha complex, enhanced the high affinity ligand-binding capacity of ER and stimulated ligand-dependent activation of ER-alpha. The SNCG-mediated stimulation of ER-alpha transcriptional activity is consistent with its stimulation of mammary tumorigenesis in response to estrogen. SNCG overexpression stimulated the ductal branching of mammary glands in SNCG transgenic mice. These data indicate that SNCG is a new chaperone protein in the Hsp-based multiprotein chaperone complex for stimulation of ligand-dependent ER-alpha signaling and, thus, stimulates hormone responsive mammary tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA429052
Entities
People
- Yangfu Jiang
Organizations
- Long Island Jewish Medical Center