Replacing the Nucleobases in DNA with Designer Molecules

Abstract

DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 26, 2003
Accession Number
ADA429279

Entities

People

  • Eric T. Kool

Organizations

  • Stanford University

Tags

Communities of Interest

  • Air Platforms
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Aromatic Polycyclic Hydrocarbons
  • Chemical Synthesis
  • Chemistry
  • Dyes
  • Fluorescence
  • Fluorophores
  • Hydrocarbons
  • Hydrogen Bonds
  • Laser Dyes
  • Materials Science
  • Molecules
  • Nucleic Acids
  • Nucleosides
  • Nucleotides
  • Organic Chemistry
  • Spine

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Nanocomposite Materials Science
  • Systems Analysis and Design

Technology Areas

  • Biotechnology