Syntheses and Characterizations of Smart and Biodegradable Dendritic Nanoparticles for Controlled Drug Delivery

Abstract

In order to transport therapeutic agents across blood brain barrier (BBB) for sustained time in response to biological need we designed and synthesized novel dendritic nanoparticles with thermoresponsive and biodegradable properties as drug delivery systems. The nano-sized dendrimer was prepared by coupling reaction of poly(L-lysine) (PLL) dendron and poly(N- isopropylacrylamide) (PNIPAAM) grafted with poly(L-lactic acid) (PLLA). The chemical structure and molar mass of the dendrimer was characterized and confirmed by fourier transform infrared spectroscopy (FTIR) and matrix assisted laser desorption/ionization time of flight mass spectroscopy (MALDI-TOF). The dendrimer was responsive to temperature changes by showing lower critical solution temperature (LCST) measured by UV-VIS spectroscopy. The LCST depended on the concentrations of the dendrimer. The dendrimer also demonstrated biodegradable properties with decreasing their molar mass as a function of time.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA429281

Entities

People

  • T. L. Lowe
  • Y. S. Kim

Organizations

  • Pennsylvania State University

Tags

Communities of Interest

  • Biomedical
  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Amines
  • Blood
  • Blood Vessels
  • Blood-Brain Barrier
  • Central Nervous System
  • Chemistry
  • Chlorides
  • Dendrimers
  • Endothelial Cells
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Materials
  • Materials Science
  • Nanomaterials
  • Nanoparticles
  • Nervous System
  • Polymers

Fields of Study

  • Materials science

Readers

  • Nanocomposite Materials Science
  • Polymer Science and Technology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech
  • Directed Energy
  • Directed Energy - Pulsed-Laser Deposition