Hadamard Transform Time-of-Flight Mass Spectrometry
Abstract
This program applied the Hadamard transform method to atmospheric pressure ion mobility separation (IMS) for the analysis of trace species. Target applications include chemical and biological agent detection as well as protein sequencing and identification. We demonstrate that the Hadamard transform approach improves sensitivity by increasing sample throughput, yet requires only minimal modification to the existing hardware. In Phase I we programmed commercially available DSP electronics that operated an existing IMS for Hadamard transform modulation and collected ion signal synchronous with yet at higher rates than the Hadamard modulation sequence. This strategy allows for parsing of the analog signal to avoid noise associated with the pulsing of the Bradbury Nielson ion gate and also allowed for easy comparison of various modulation rates and sequence lengths.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 30, 2004
- Accession Number
- ADA429458
Entities
People
- Steve Massick