Biodegradable-co-bioresponsive Hydrogels for Controlled Release of Growth Factor

Abstract

A series of multi-functional hydrogel systems have been designed and synthesized for potential brain implantation to realize controlled and sustained release of Nerve Growth Factor (NGF) for the treatment of Alzheimer's disease (AD). The systems are three-dimensional crosslinked copolymers composed of a thermo-responsive unit, a hydrolytically degradable and hydrophobic unit, and an enzymatically degradable and hydrophilic unit. They combine the merits of thermo-responsive and biodegradable polymeric drug delivery systems, and allow a low-temperature aqueous NGF loading to prevent protein denaturation. The hydrogels show a lower critical solution temperature (LCST) at approximately 32 oC, and demonstrate different swelling and release profiles at temperatures above (37 oC) and below (25 oC) the LCST.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA429561

Entities

People

  • B. R. Nayak
  • T. L. Lowe
  • Xinyi Huang

Organizations

  • Pennsylvania State University

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Blood-Brain Barrier
  • Central Nervous System
  • Chemical Compounds
  • Chemistry
  • Diseases And Disorders
  • Gels
  • Growth Factors
  • Hydrogels
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Lactic Acid
  • Materials
  • Materials Science
  • Nervous System
  • Neurons
  • Three Dimensional

Readers

  • Polymer Science and Technology
  • Trauma Surgery or Emergency Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Microelectronics