Development of a Novel Tissue Adhesive using a Naturally-Derived Small Molecule

Abstract

A citric acid derivative (CAD) with three active ester groups in a molecule was prepared in order to develop a novel tissue adhesive consisting of CAD and collagen (CAD-C glue). The bonding strength of CAD-C glue to porcine soft tissues had high value similar to the tearing strength of the original soft tissue. The cytotoxicity of CAD for L929 fibroblast was 10 times less cytotoxic than that of glutaraldehyde and formaldehyde that are used in gelatin-resorcinol-formaldehyde glue. This adhesive developed will be applied as bonding reagent for soft tissues.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA429595

Entities

People

  • H. Kobayashi
  • H. Saito
  • J. Tanaka
  • K. Kataoka
  • T. Taguchi

Organizations

  • University of Tokyo

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Adhesives
  • Biomedical And Dental Materials
  • Cells
  • Citric Acid
  • Collagen
  • Culture Techniques
  • Esters
  • Formaldehyde
  • Materials
  • Molecules
  • Polymers
  • Small Molecules
  • Soft Tissues
  • Tissue Adhesives
  • Tissues
  • Wound Healing

Readers

  • Molecular and Cellular Biochemistry
  • Structural Health Monitoring of Composite Structures.
  • Trauma Surgery or Emergency Medicine.