Magnetic Nanoparticles for Manipulation and Control of Biological Processes
Abstract
We explored the potential of magnetic nanoparticles (MNPs) for manipulation and control of cell functions using magnetic fields. We synthesized several types of MNPs, functionalize their surfaces to make them biocompatible, and bind them to cells. The investigation then focused on two phenomena, magnetoporation and AC magnetic field heating. In the magnetoporation experiments, we applied pulses of a magnetic field gradient to briefly open cell membranes. In the AC magnetic field heating experiments, we raised the local temperature via excitation of the MNPs chosen to maximize dissipative losses, and monitor the effect on cell viability.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA429731
Entities
People
- George Majetich
- Luz J. Martinez-miranda
- Sara Majetich
- Sheryl H. Ehrman
- Tracy R. Pulliam-holoman
Organizations
- University of Maryland